Two sample MR report

Telomere_length against aparc-a2009s rh area S-orbital-med-olfact

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0433462	0.1073471	0.6904463
Weighted median	23	-0.0248954	0.0515201	0.6289418
Inverse variance weighted	23	-0.0517644	0.0409911	0.2066541
Simple mode	23	0.0192396	0.0831690	0.8191954
Weighted mode	23	-0.0132675	0.0601728	0.8275232

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.48914	21	0.2699665
Inverse variance weighted	24.49761	22	0.3216968

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005169	0.006067	0.9329137

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007961	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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