Two sample MR report

Telomere_length against aparc-a2009s rh area S-orbital-lateral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0427589	0.0994092	0.6714825
Weighted median	23	-0.0145760	0.0546091	0.7895342
Inverse variance weighted	23	-0.0133207	0.0388467	0.7316694
Simple mode	23	-0.0406931	0.0972689	0.6797420
Weighted mode	23	-0.0406931	0.0658581	0.5429911

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.79993	21	0.8328554
Inverse variance weighted	14.90343	22	0.8663490

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018075	0.0056184	0.7508513

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004552	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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