Two sample MR report

Telomere_length against aparc-a2009s rh area S-orbital-H-Shaped

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0084993	0.1365103	0.9509437
Weighted median	23	0.0178089	0.0650495	0.7842584
Inverse variance weighted	23	-0.0464231	0.0523546	0.3752385
Simple mode	23	0.0928297	0.1192673	0.4446638
Weighted mode	23	0.0491588	0.0803675	0.5470223

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.60272	21	0.0083085
Inverse variance weighted	39.96299	22	0.0109198

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033723	0.0077153	0.6665112

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012542	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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