Two sample MR report

Telomere_length against aparc-a2009s rh area S-oc-temp-med+Lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1824618	0.0994062	0.0806321
Weighted median	23	-0.0161697	0.0570787	0.7769557
Inverse variance weighted	23	-0.0353717	0.0404994	0.3824525
Simple mode	23	0.0259449	0.0946438	0.7865406
Weighted mode	23	0.0094945	0.0638225	0.8830948

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.24600	21	0.6333876
Inverse variance weighted	23.91345	22	0.3517825

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0133748	0.0056182	0.0268301

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007498	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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