Two sample MR report

Telomere_length against aparc-a2009s rh area S-oc-temp-lat

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0326856	0.1233924	0.7936754
Weighted median	23	-0.0337099	0.0590255	0.5679270
Inverse variance weighted	23	-0.0709991	0.0480356	0.1393933
Simple mode	23	-0.0077288	0.0839814	0.9275072
Weighted mode	23	-0.0179401	0.0637187	0.7809184

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.35752	21	0.0538448
Inverse variance weighted	33.64155	22	0.0534015

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063662	0.0069738	0.3716723

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011205	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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