Two sample MR report

Telomere_length against aparc-a2009s rh area S-oc-sup+transversal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0647966	0.0994057	0.5215752
Weighted median	23	0.0119132	0.0545863	0.8272375
Inverse variance weighted	23	0.0330682	0.0388454	0.3946155
Simple mode	23	0.0486278	0.0920911	0.6027572
Weighted mode	23	0.0316292	0.0658112	0.6355412

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.42349	21	0.8930681
Inverse variance weighted	14.56741	22	0.8801245

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060089	0.0056182	0.2969648

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004634	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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