Two sample MR report

Telomere_length against aparc-a2009s rh area S-oc-middle+Lunatus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0310658	0.0994065	0.7577328
Weighted median	23	-0.0268056	0.0563328	0.6341855
Inverse variance weighted	23	-0.0055497	0.0388455	0.8863959
Simple mode	23	-0.0578144	0.0853660	0.5053055
Weighted mode	23	-0.0238419	0.0615132	0.7020433

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.64498	21	0.4808002
Inverse variance weighted	20.72274	22	0.5379251

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015667	0.0056182	0.7830818

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006286	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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