Two sample MR report

Telomere_length against aparc-a2009s rh area S-occipital-ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1874409	0.0994074	0.0732619
Weighted median	23	0.0773314	0.0573394	0.1774454
Inverse variance weighted	23	0.0748071	0.0388461	0.0541382
Simple mode	23	-0.0275257	0.0943638	0.7732504
Weighted mode	23	0.0608831	0.0686115	0.3844838

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.58794	21	0.8866402
Inverse variance weighted	15.10313	22	0.8577744

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0069158	0.0056183	0.2319583

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00057	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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