Two sample MR report

Telomere_length against aparc-a2009s rh area S-intrapariet+P-trans

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0605641	0.1039948	0.5665139
Weighted median	23	0.0223158	0.0569334	0.6950858
Inverse variance weighted	23	0.0014399	0.0400631	0.9713297
Simple mode	23	-0.0064591	0.1012488	0.9497102
Weighted mode	23	0.0546682	0.0712050	0.4507930

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.98344	21	0.3448621
Inverse variance weighted	23.40095	22	0.3793935

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036302	0.0058775	0.5434519

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007091	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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