Two sample MR report

Telomere_length against aparc-a2009s rh area S-interm-prim-Jensen

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0133652	0.1024346	0.8974323
Weighted median	23	0.0597096	0.0586175	0.3083787
Inverse variance weighted	23	0.0075637	0.0391115	0.8466561
Simple mode	23	-0.1411233	0.1106756	0.2155732
Weighted mode	23	-0.1462734	0.0837415	0.0946337

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.29606	21	0.3826245
Inverse variance weighted	22.30008	22	0.4421041

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003562	0.0057894	0.9515201

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006768	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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