Two sample MR report

Telomere_length against aparc-a2009s rh area S-front-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1346637	0.1187256	0.2694746
Weighted median	23	-0.0578094	0.0576967	0.3163655
Inverse variance weighted	23	-0.0654818	0.0457584	0.1524206
Simple mode	23	-0.0490870	0.1070633	0.6511003
Weighted mode	23	-0.0525690	0.0759578	0.4961262

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.95613	21	0.0928731
Inverse variance weighted	30.52778	22	0.1061907

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042478	0.0067101	0.5335422

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010111	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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