Two sample MR report

Telomere_length against aparc-a2009s rh area S-front-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2128935	0.1264531	0.1070718
Weighted median	23	0.0342120	0.0561750	0.5425076
Inverse variance weighted	23	0.0076995	0.0517279	0.8816751
Simple mode	23	0.0438208	0.0913567	0.6361981
Weighted mode	23	0.0395032	0.0631501	0.5380493

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.98281	21	0.0363932
Inverse variance weighted	39.01174	22	0.0140683

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0125988	0.0071468	0.0924724

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011832	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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