Two sample MR report

Telomere_length against aparc-a2009s rh area S-front-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2301001	0.1173098	0.0632169
Weighted median	23	-0.0912205	0.0568138	0.1083607
Inverse variance weighted	23	-0.0785291	0.0468419	0.0936457
Simple mode	23	-0.1731162	0.1044887	0.1117554
Weighted mode	23	-0.1335221	0.0681772	0.0629748

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.24674	21	0.1082026
Inverse variance weighted	31.99076	22	0.0775537

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0093065	0.0066301	0.1750331

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010932	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8