Two sample MR report

Telomere_length against aparc-a2009s rh area S-collat-transv-post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0381855	0.1258055	0.7644742
Weighted median	23	0.0266152	0.0549360	0.6280472
Inverse variance weighted	23	0.0388590	0.0485354	0.4233445
Simple mode	23	-0.0655486	0.1049789	0.5387880
Weighted mode	23	0.0002065	0.0617989	0.9973634

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.63415	21	0.0396414
Inverse variance weighted	34.34310	22	0.0453155

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047305	0.0071102	0.5130924

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001071	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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