Two sample MR report

Telomere_length against aparc-a2009s rh area S-collat-transv-ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0530712	0.1011041	0.6051395
Weighted median	23	-0.0255534	0.0560781	0.6486238
Inverse variance weighted	23	-0.0670252	0.0388450	0.0844461
Simple mode	23	0.0012221	0.1029166	0.9906323
Weighted mode	23	-0.0178454	0.0835652	0.8328642

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.72382	21	0.4155722
Inverse variance weighted	21.74707	22	0.4750694

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008568	0.0057142	0.8822437

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007492	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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