Two sample MR report

Telomere_length against aparc-a2009s rh area S-circular-insula-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1260736	0.1325617	0.3523947
Weighted median	23	-0.0932603	0.0584877	0.1108178
Inverse variance weighted	23	-0.0151725	0.0515968	0.7687136
Simple mode	23	-0.1370260	0.1174652	0.2558924
Weighted mode	23	-0.1150038	0.0657247	0.0940937

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.34468	21	0.0153631
Inverse variance weighted	38.81365	22	0.0148216

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0068093	0.0074921	0.373733

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011807	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8