Two sample MR report

Telomere_length against aparc-a2009s rh area S-circular-insula-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0713605	0.1174245	0.5498938
Weighted median	23	0.0573304	0.0558171	0.3043682
Inverse variance weighted	23	0.0345366	0.0458450	0.4512491
Simple mode	23	0.0486082	0.0953191	0.6151627
Weighted mode	23	0.0409419	0.0630454	0.5228008

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.30352	21	0.1069032
Inverse variance weighted	30.64294	22	0.1036566

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006502	0.0066365	0.3383704

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009525	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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