Two sample MR report

Telomere_length against aparc-a2009s rh area S-circular-insula-ant

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0432766 0.1053142 0.6852883
Weighted median 23 -0.0057336 0.0551686 0.9172260
Inverse variance weighted 23 -0.0259280 0.0402385 0.5193437
Simple mode 23 0.0420811 0.0874065 0.6349568
Weighted mode 23 0.0026362 0.0595914 0.9651137

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.56892 21 0.3144105
Inverse variance weighted 23.60487 22 0.3682768

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0010652 0.0059522 0.8596832

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007288 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8