Two sample MR report

Telomere_length against aparc-a2009s rh area S-cingul-Marginalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0483256	0.1137827	0.6753617
Weighted median	23	-0.0123575	0.0584186	0.8324709
Inverse variance weighted	23	0.0014324	0.0436478	0.9738208
Simple mode	23	-0.0163095	0.1009181	0.8730868
Weighted mode	23	-0.0199938	0.0813770	0.8081969

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.51359	21	0.154493
Inverse variance weighted	27.77623	22	0.183216

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028792	0.0064307	0.6589324

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008417	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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