Two sample MR report

Telomere_length against aparc-a2009s rh area S-central

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0088651	0.1181834	0.9409157
Weighted median	23	0.0129621	0.0605508	0.8304930
Inverse variance weighted	23	-0.0194561	0.0451313	0.6663955
Simple mode	23	-0.0561048	0.0917468	0.5471247
Weighted mode	23	0.0222343	0.0732907	0.7644571

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.68289	21	0.0985479
Inverse variance weighted	29.69629	22	0.1260349

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006503	0.0066794	0.9233666

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009074	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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