Two sample MR report

Telomere_length against aparc-a2009s rh area S-calcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0554331	0.1034919	0.5978440
Weighted median	23	0.0329072	0.0615540	0.5929220
Inverse variance weighted	23	0.0398716	0.0395376	0.3132391
Simple mode	23	-0.0338058	0.1169511	0.7752421
Weighted mode	23	-0.0484849	0.1102110	0.6642807

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.76291	21	0.3567489
Inverse variance weighted	22.79183	22	0.4135629

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009555	0.0058492	0.8718026

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007226	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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