Two sample MR report

Telomere_length against aparc-a2009s rh area Pole-temporal

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0782100 0.1027426 0.4549878
Weighted median 23 -0.0135518 0.0560811 0.8090538
Inverse variance weighted 23 0.0076722 0.0399893 0.8478543
Simple mode 23 -0.0236445 0.1034861 0.8213832
Weighted mode 23 -0.0581044 0.0699878 0.4153408

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 22.43417 21 0.3748716
Inverse variance weighted 23.31515 22 0.3841211

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0052732 0.0058068 0.3741264

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007077 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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