Two sample MR report

Telomere_length against aparc-a2009s rh area Pole-occipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0472097	0.1129584	0.6802344
Weighted median	23	0.0804307	0.0601263	0.1809958
Inverse variance weighted	23	0.0194657	0.0435466	0.6548680
Simple mode	23	-0.1134267	0.1240161	0.3703112
Weighted mode	23	0.1145110	0.0897239	0.2151730

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.11684	21	0.1670193
Inverse variance weighted	27.64782	22	0.1876482

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040939	0.0063842	0.5282949

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008454	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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