Two sample MR report

Telomere_length against aparc-a2009s rh area Lat-Fis-ant-Vertical

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1604516	0.1265748	0.2188020
Weighted median	23	0.1025154	0.0624419	0.1006372
Inverse variance weighted	23	0.0099380	0.0502104	0.8431016
Simple mode	23	0.1804003	0.1157000	0.1332177
Weighted mode	23	0.1257208	0.0739717	0.1033077

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.03614	21	0.0359179
Inverse variance weighted	36.74102	22	0.0252506

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0092419	0.007154	0.2104446

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011153	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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