Two sample MR report

Telomere_length against aparc-a2009s rh area Lat-Fis-ant-Horizont

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0487657	0.1066659	0.6522345
Weighted median	23	-0.0555349	0.0618505	0.3692449
Inverse variance weighted	23	0.0095784	0.0410650	0.8155676
Simple mode	23	-0.0677070	0.1180803	0.5721905
Weighted mode	23	-0.0876456	0.0942319	0.3624108

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.17840	21	0.2844952
Inverse variance weighted	24.58495	22	0.3173313

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035824	0.0060286	0.5587064

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007468	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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