Two sample MR report

Telomere_length against aparc-a2009s rh area G-temp-sup-Plan-tempo

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0256355	0.1030841	0.8060199
Weighted median	23	-0.0221033	0.0565136	0.6957121
Inverse variance weighted	23	-0.0217103	0.0395892	0.5834247
Simple mode	23	0.0391141	0.0880991	0.6613949
Weighted mode	23	-0.0141962	0.0592193	0.8127644

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.58267	21	0.3666264
Inverse variance weighted	22.85040	22	0.4102178

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002907	0.005826	0.6229888

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007019	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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