Two sample MR report

Telomere_length against aparc-a2009s rh area G-temp-sup-Plan-polar

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0330101	0.1172074	0.7809778
Weighted median	23	-0.0590767	0.0564225	0.2950807
Inverse variance weighted	23	-0.0095981	0.0447989	0.8303531
Simple mode	23	-0.0961402	0.1052012	0.3706926
Weighted mode	23	-0.0722917	0.0647011	0.2759120

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.19543	21	0.1093882
Inverse variance weighted	29.26089	22	0.1375619

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014375	0.0066243	0.8303006

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008885	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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