Two sample MR report

Telomere_length against aparc-a2009s rh area G-temp-sup-Lateral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0022364	0.1240089	0.9857821
Weighted median	23	-0.0738112	0.0543992	0.1748310
Inverse variance weighted	23	-0.0711092	0.0477541	0.1364686
Simple mode	23	0.0237730	0.1024459	0.8186406
Weighted mode	23	-0.0541313	0.0640945	0.4074506

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.68197	21	0.0498647
Inverse variance weighted	33.24853	22	0.0584623

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0042288	0.0070087	0.5527296

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011089	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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