Two sample MR report

Telomere_length against aparc-a2009s rh area G-temp-sup-G-T-transv

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0914870	0.1008141	0.3744480
Weighted median	23	-0.0071515	0.0572823	0.9006455
Inverse variance weighted	23	-0.0123415	0.0391509	0.7525878
Simple mode	23	0.0480779	0.1074907	0.6590491
Weighted mode	23	-0.0320643	0.0671144	0.6375368

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.59838	21	0.4229614
Inverse variance weighted	22.34651	22	0.4393763

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048595	0.0056978	0.4033487

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006802	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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