Two sample MR report

Telomere_length against aparc-a2009s rh area G-temporal-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0477387	0.1018965	0.6442520
Weighted median	23	-0.0240107	0.0561652	0.6690140
Inverse variance weighted	23	-0.0112155	0.0390434	0.7739149
Simple mode	23	0.0255958	0.0969624	0.7942547
Weighted mode	23	-0.0523578	0.0649327	0.4286782

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.06568	21	0.3957332
Inverse variance weighted	22.22501	22	0.4465289

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022425	0.005759	0.7009032

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000676	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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