Two sample MR report

Telomere_length against aparc-a2009s rh area G-temporal-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0291654	0.1032416	0.7803283
Weighted median	23	0.0618073	0.0577035	0.2841154
Inverse variance weighted	23	0.0036188	0.0394845	0.9269759
Simple mode	23	0.0188745	0.1067193	0.8612358
Weighted mode	23	0.0407781	0.0750403	0.5923073

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.65238	21	0.3627891
Inverse variance weighted	22.73033	22	0.4170884

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015686	0.005835	0.7906914

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000689	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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