Two sample MR report

Telomere_length against aparc-a2009s rh area G-subcallosal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0543003	0.0994064	0.5906541
Weighted median	23	-0.0598814	0.0514822	0.2447693
Inverse variance weighted	23	-0.0358123	0.0388455	0.3565732
Simple mode	23	-0.0698066	0.0853954	0.4224357
Weighted mode	23	-0.0620136	0.0619646	0.3278092

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.20819	21	0.8604918
Inverse variance weighted	14.24901	22	0.8924062

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011352	0.0056182	0.8418222

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004575	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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