Two sample MR report

Telomere_length against aparc-a2009s rh area G-rectus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0670683	0.1394745	0.6355850
Weighted median	23	-0.0229157	0.0687435	0.7388699
Inverse variance weighted	23	-0.0386507	0.0533119	0.4684569
Simple mode	23	0.1402681	0.1455357	0.3456189
Weighted mode	23	0.0954536	0.1089539	0.3904458

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.34314	21	0.0050837
Inverse variance weighted	41.43960	22	0.0073025

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017448	0.0078828	0.8269598

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012857	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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