Two sample MR report

Telomere_length against aparc-a2009s rh area G-precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0612405	0.1400530	0.6663820
Weighted median	23	-0.0033184	0.0575354	0.9540073
Inverse variance weighted	23	0.0277199	0.0540735	0.6082070
Simple mode	23	-0.0212447	0.0798932	0.7927813
Weighted mode	23	-0.0046536	0.0567559	0.9353941

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.68483	21	0.0046085
Inverse variance weighted	42.63005	22	0.0052391

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054621	0.0079154	0.4977129

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013071	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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