Two sample MR report

Telomere_length against aparc-a2009s rh area G-precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0047632	0.0994066	0.9622356
Weighted median	23	-0.0324772	0.0582419	0.5771003
Inverse variance weighted	23	-0.0347921	0.0388454	0.3704376
Simple mode	23	-0.0042554	0.0851715	0.9606033
Weighted mode	23	-0.0176511	0.0652175	0.7891839

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.97798	21	0.6503974
Inverse variance weighted	18.08568	22	0.7008966

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018438	0.0056182	0.746029

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005723	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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