Two sample MR report

Telomere_length against aparc-a2009s rh area G-postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0463377	0.1171551	0.6964455
Weighted median	23	0.0273526	0.0640155	0.6691751
Inverse variance weighted	23	-0.0501956	0.0447298	0.2617790
Simple mode	23	0.0915762	0.1256864	0.4739262
Weighted mode	23	0.0781562	0.0782021	0.3284610

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.16907	21	0.1100011
Inverse variance weighted	29.17085	22	0.1400472

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002369	0.0066213	0.9717998

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009345	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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