Two sample MR report

Telomere_length against aparc-a2009s rh area G-pariet-inf-Supramar

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0374738	0.1324947	0.7800742
Weighted median	23	-0.0717264	0.0621062	0.2481313
Inverse variance weighted	23	-0.0575626	0.0513111	0.2619330
Simple mode	23	-0.1351337	0.1221042	0.2803748
Weighted mode	23	-0.0797617	0.0784673	0.3204425

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.30788	21	0.0155144
Inverse variance weighted	38.38665	22	0.0165734

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0058352	0.0074883	0.4445291

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012296	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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