Two sample MR report

Telomere_length against aparc-a2009s rh area G-parietal-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1250804	0.1028910	0.2376051
Weighted median	23	0.0721031	0.0593645	0.2245257
Inverse variance weighted	23	0.0105519	0.0406275	0.7950765
Simple mode	23	-0.1825319	0.1305522	0.1760049
Weighted mode	23	0.0862605	0.0792974	0.2884538

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.49845	21	0.3712910
Inverse variance weighted	24.06509	22	0.3438267

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.007032	0.0058152	0.2400032

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007315	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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