Two sample MR report

Telomere_length against aparc-a2009s rh area G-orbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0396973	0.1420664	0.7826500
Weighted median	23	0.0341358	0.0642673	0.5953129
Inverse variance weighted	23	0.0077094	0.0543166	0.8871314
Simple mode	23	0.0644687	0.1250097	0.6112015
Weighted mode	23	0.0557501	0.0873613	0.5299597

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.89301	21	0.0032437
Inverse variance weighted	43.01523	22	0.0046988

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001964	0.0080292	0.8091316

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013045	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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