Two sample MR report

Telomere_length against aparc-a2009s rh area G-oc-temp-med-Lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1255265	0.1166340	0.2940283
Weighted median	23	0.0622898	0.0634223	0.3260291
Inverse variance weighted	23	-0.0139144	0.0456615	0.7605718
Simple mode	23	0.0726963	0.1149029	0.5334665
Weighted mode	23	0.0456862	0.0807726	0.5773794

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.91046	21	0.1161678
Inverse variance weighted	30.39836	22	0.1090992

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006853	0.0065919	0.3103451

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000925	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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