Two sample MR report

Telomere_length against aparc-a2009s rh area G-oc-temp-lat-fusifor

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1062684	0.1101712	0.3457350
Weighted median	23	0.0290990	0.0597662	0.6263433
Inverse variance weighted	23	0.0550684	0.0423170	0.1931461
Simple mode	23	0.0094636	0.0959329	0.9223111
Weighted mode	23	0.0546624	0.0760163	0.4796562

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.79525	21	0.2143641
Inverse variance weighted	26.10835	22	0.2470591

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031437	0.0062267	0.6189028

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000852	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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