Two sample MR report

Telomere_length against aparc-a2009s rh area G-occipital-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0086610	0.1018338	0.9330273
Weighted median	23	-0.0141478	0.0586054	0.8092390
Inverse variance weighted	23	-0.0145294	0.0389358	0.7090264
Simple mode	23	-0.0665209	0.1193217	0.5828198
Weighted mode	23	0.1126486	0.0881026	0.2143597

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.03897	21	0.3972672
Inverse variance weighted	22.10320	22	0.4537432

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014239	0.0057555	0.8070017

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000674	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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