Two sample MR report

Telomere_length against aparc-a2009s rh area G-occipital-middle

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0027354 0.1045486 0.9793736
Weighted median 23 -0.0200394 0.0544217 0.7127064
Inverse variance weighted 23 -0.0041117 0.0399202 0.9179642
Simple mode 23 -0.0230540 0.0932419 0.8070079
Weighted mode 23 -0.0097735 0.0654779 0.8827052

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.22861 21 0.3319114
Inverse variance weighted 23.23421 22 0.3886070

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0004204 0.0059088 0.943952

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007043 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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