Two sample MR report

Telomere_length against aparc-a2009s rh area G-insular-short

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0630850	0.1135518	0.5843811
Weighted median	23	-0.0562811	0.0560186	0.3150481
Inverse variance weighted	23	-0.0278015	0.0434702	0.5224635
Simple mode	23	-0.0079166	0.1004032	0.9378660
Weighted mode	23	-0.0582742	0.0732369	0.4347116

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.40206	21	0.1579379
Inverse variance weighted	27.55076	22	0.1910510

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021664	0.0064177	0.7390402

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008504	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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