Two sample MR report

Telomere_length against aparc-a2009s rh area G-front-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0388287	0.1208349	0.7511316
Weighted median	23	0.0206916	0.0559452	0.7114901
Inverse variance weighted	23	-0.0063956	0.0463147	0.8901691
Simple mode	23	-0.0233928	0.0963022	0.8103252
Weighted mode	23	0.0292090	0.0662714	0.6636958

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.02973	21	0.0731647
Inverse variance weighted	31.27400	22	0.0906436

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027768	0.0068293	0.6884197

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009484	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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