Two sample MR report

Telomere_length against aparc-a2009s rh area G-front-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0551418	0.1211458	0.6536585
Weighted median	23	-0.0230008	0.0567241	0.6851206
Inverse variance weighted	23	-0.0714821	0.0462759	0.1224204
Simple mode	23	0.0258996	0.1016110	0.8011759
Weighted mode	23	0.0393475	0.0826812	0.6388418

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.19034	21	0.0705480
Inverse variance weighted	31.22223	22	0.0916569

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010033	0.0068469	0.8848989

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010487	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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