Two sample MR report

Telomere_length against aparc-a2009s rh area G-front-inf-Triangul

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0277197	0.1351005	0.8394087
Weighted median	23	-0.0681781	0.0564126	0.2268310
Inverse variance weighted	23	-0.0469864	0.0516100	0.3626052
Simple mode	23	-0.0203548	0.1200924	0.8669577
Weighted mode	23	-0.0778914	0.0661535	0.2516031

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.78954	21	0.010399
Inverse variance weighted	38.83388	22	0.014743

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001183	0.0076356	0.8783562

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001221	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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