Two sample MR report

Telomere_length against aparc-a2009s rh area G-front-inf-Orbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0241872	0.1099067	0.8279415
Weighted median	23	0.0077819	0.0567029	0.8908418
Inverse variance weighted	23	0.0230817	0.0421789	0.5842194
Simple mode	23	-0.1184902	0.1074146	0.2818996
Weighted mode	23	-0.0347030	0.0648293	0.5978137

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.66946	21	0.2193338
Inverse variance weighted	25.93631	22	0.2544266

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029023	0.0062117	0.6451445

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007966	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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