Two sample MR report

Telomere_length against aparc-a2009s rh area G-front-inf-Opercular

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1615671	0.1031924	0.1323674
Weighted median	23	-0.0651236	0.0603512	0.2805531
Inverse variance weighted	23	-0.0681749	0.0402949	0.0906651
Simple mode	23	-0.0658723	0.0969754	0.5040521
Weighted mode	23	-0.0630217	0.0804162	0.4415757

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.63155	21	0.3639332
Inverse variance weighted	23.67336	22	0.3645812

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0057343	0.0058323	0.3366975

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008107	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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