Two sample MR report

Telomere_length against aparc-a2009s rh area G-cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1107698	0.1390637	0.4346315
Weighted median	23	0.0380250	0.0643697	0.5547025
Inverse variance weighted	23	0.0183905	0.0537484	0.7322308
Simple mode	23	0.0098492	0.1335949	0.9418962
Weighted mode	23	-0.1493472	0.1384449	0.2923858

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.10208	21	0.0054463
Inverse variance weighted	42.12145	22	0.0060426

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056722	0.0078597	0.4784504

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012831	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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